The launch of the partnership is marked by the release of LFC 'emoticons' which will be available on Skype.
These include wearing an LFC scarf with their fingers crossed, thumbs up and covering eyes - all three of which were launched on Monday.
The first set will also include mini versions of the Reds manager, Jürgen Klopp, captain Jordan Henderson, and team-mates Philippe Coutinho and Daniel Sturridge.
Skype will also launch an Official LFC Skype ID which will enable fans to interact with each other in group chats during key games.
By connecting with LFCofficial on Skype from January 12, fans will be offered content from first team players, as well as the chance to win signed merchandise.
Billy Hogan, Liverpool's chief commercial officer, said: “Skype is one of those essential communication tools that people use to interact with friends and family across the world.
"Through this partnership we’re enabling Liverpool FC’s global family to interact with the club and we’re delighted to be working together so closely on this great piece of innovation that our fans can enjoy every day.”